lysosome相关论文
胆固醇是人类基本生命活动中的一类重要的甾醇类分子,由一个环戊烷多氢菲的甾核以及烷基侧链组成。胆固醇参与细胞膜的形成,同时也......
Programmed cell death ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) cascade is an effective therapeutic target......
Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in
We have previously shown that roflupram (ROF) protects against MPP+-induced neuronal damage in models of Parkinson\'s ......
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EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise its effectiveness in lung ca
Objective Lung cancer is the most frequent cause of cancer-associated deaths worldwide,and NSCLC(non-small cell lung can......
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Background Heat shock factor 4,which is a regulator of heat shock response by upregulating the expression of heat shock ......
Microglia are highly motile cells that act as the main form of active immune defense in the central nervous system.Attra......
Objective Autophagy is a process which can be activated during various stress conditions.Our previous study reported tha......
The contribution of autophagy-lysosomal pathway to neuronal death and its underlying mechanisms in t
Objective To investigate activation of autophagy by permanent focal cerebral ischemia,the effects of blocking autophagy-......
Autophagy dysfunction is considered as a potential toxic mechanism of nanomaterials1.Silica nanoparticles(SiNPs) induced......
Quantitative Analysis of Interactive Behavior of Mitochondria and Lysosomes Using Structured Illumin
Super-resolution optical microscopy has extended the scope of cell biology from the cellular level to the nanoscale,givi......
Chymotrypsin B:Not Just a Digestive Enzyme, But Involved in Oxidative Stress-Induced Apoptosis via a
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Lysosome, the cells recycling center, is required for the cells to eliminate waste materials and cellular debris.Recent ......
A lysosome-targeted and two-photon excitable iridium(Ⅲ)complex for bimodal visualization of endogeno
Nitric oxide(NO)is a fundamental signaling molecule that shows complex effects on the catabolic autophagy process,which ......
Dual Functions of Cyclometalated Iridium(Ⅲ)Complexes:Anti-metastasis and Lysosome-damaged Photodynam
Cancer metastasis and drug resistance lead to treatment difficulty and increasing mortality rates....
Fluorescent probes are powerful tools for biosensing and bioimaging due to their high sensitivity,specificity,rapid resp......
Many Phosphorescent iridium complexes potent candidates for photodynamic therapeutic agents....
Three lysosome-targetable fluorescence probes for sensitively and selectively monitoring subcellular
As the advanced organelles found in eukaryotic cells,lysosomes are considered crucial regulators of cell homeostasis.The......
Light-induced translocation of CPE in cells: polymer design, synthesis, and applications in cell ima
In our previous work,1 we synthesized PPET3-N2 and demonstrated its potential application in cell imaging.In the current......
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Many neurodegenerative diseases are characterized by abnormal accumulations of insoluble protein aggregates, such as......
γ-L-glutamyl-S-[2-[[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl]oxy]carbonyl......
Caveolin-1 (CAV1) is well known as a principle scaffolding protein of caveolae, a specialized plasma membrane struct......
Autophagy helps deliver sequestered intracellular cargo to lysosomes for proteolytic degradation and thereby maintai......
应用电子显微镜观察了大鼠第２段近端肾小管溶酶体系统超微结构。用显微分光光度计对溶酶体标志酶酸性磷酸酶和芳香硫酸酯酶作了测定......
Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the most abundant sterol in mammals......
Lipid rafts participate in aberrant degradative autophagic-lysosomal pathway of amyloid-beta peptide
Amyloid-beta peptide is the main component of amyloid plaques, which are found in Alzhei-mer’s disease. The generation ......
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荷脂细胞胆固醇逆向转运(RCT)能力是决定动脉粥样硬化(AS)病程的关键。自噬促进RCT是其重要调控方式,然而在动脉粥样硬化中自噬的......
Background: High proliferative rate of cancer cells requires autophagy to maintain nutrient supply and intracellular hom......
The Distribution of Synaptotagmin Ⅱ in RBL-2H3 and Its Regulation on Exocytosis of Lysosomes in RBL-
Synaptotagmin (Syt) constitutes a family of membrane-trafficking proteins, so far nearly 20 Syts have been discovered. E......
利用Suzuki偶联反应合成了疏水性寡聚芴分子OF,并对其在氯仿溶液中的紫外吸收和荧光光谱进行了表征,表明其具有较大的摩尔吸光系数......
细胞应对细菌或病毒感染及来自环境的各种化学药物时常表现为在细胞质内形成大量空泡，其中有些空泡来源于内体和溶酶体，称为内体和溶......
OBJECTIVE Identification of novel autophagy inhibitors for the combinational treatment of non-small cell lung cancer(NSC......
低效的溶酶体降解是多种脑部疾病发展的中心环节，但其具体机制及参与的细胞种类仍不清楚。既往研究显示，星形胶质细胞大量吞噬死亡的......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
目的探讨自噬小体清除水平在七氟烷预处理产生延迟性心肌保护中的作用。方法成年雄性SD大鼠45只，体质量270～350 g，采用随机数字表法，随......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
髓鞘形成是一个包括协同性的胞吐、内吞、mRNA转运和细胞骨架的动态变化的复杂过程.尽管髓鞘的异常在溶酶体贮积症中很常见,但对溶......
结核分枝杆菌是一种烈性、强毒、传染性病原菌.由其引发的结核病极难治愈,普通的抗生素药物对其根本不起作用.究其原因是该菌通过......
目的 寻找可能的骨肉瘤血清蛋白标志物,探讨溶酶体相关基因在骨肉瘤中的表达和功能.方法 分别利用基因芯片和激光解析离子化飞行时......
The subcellular localization of samarium and europium, two rare-earths, increasingly used in both medical and industrial......
目的 观察不同浓度镉离子诱导饲养对参环毛蚓体腔细胞溶酶体膜的毒性效应.方法 选取健康参环毛蚓70只,按照饲养土壤镉离子浓度的不......
组织蛋白酶是溶酶体水解蛋白酶家族的成员之一,它大量存在于活体细胞中,在细胞的蛋白水解中发挥重要作用。近年的研究表明,组织蛋......
目的观察大鼠大脑中动脉闭塞后不同时间半影区内神经元中溶酶体超微结构及酸性磷酸酶含量的变化。方法应用细胞化学电镜和彩色图像......
